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    In elucidating the

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    To date, there are twenty-four crystal structures of class A GPCRs (twenty-two with an intact transmembrane (TM) region) that have been obtained by X-ray crystallography.Specifically, GPCR structures with small differences in their TM regions (as measured by backbone root mean square deviation (RMSD)) are represented by points that are close in the two-dimensional space, whereas those with structurally dissimilar TM regions are represented by points that are farther apart.Nevertheless, production of new GPCR crystal structures has proceeded at an extremely slow pace since publication in year 2000 of the first crystal structure of prototypic class A GPCR bovine rhodopsin [2] (see reported yearly growth of available GPCR crystal structures in ).Additionally, researchers demonstrate that biomarkers -- the genes and proteins that indicate biological processes -- might help guide the selection of patients for specific clinical trials and speed-up the development of targeted cancer drugs. Bortezomib is a proteasome inhibitor, a new class of cancer drugs that target the proteasome.The proteasome is a critical structure within cells that degrades or recycles more than 90% of intracellular proteins -- it breaks down proteins that are meant to be discarded.

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